DNA Minigene Vaccination for Adjuvant Neuroblastoma Therapy

@article{Lode2004DNAMV,
  title={DNA Minigene Vaccination for Adjuvant Neuroblastoma Therapy},
  author={Holger N Lode and Nicole Huebener and Yan Zeng and Stefan Fest and Silke Weixler and Gerhard Gaedicke},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1028}
}
Abstract: The disruption of self‐tolerance against neuroblastoma is the ultimate goal of an effective DNA‐vaccine. We demonstrate the induction of protective immunity against syngeneic murine NXS2 neuroblastoma in A/J mice following vaccination with tyrosine hydroxylase (TH)‐derived antigens. Oral gene delivery was accomplished using an attenuated strain of Salmonella typhimurium as a carrier harboring vectors encoding for mouse tyrosine hydroxylase (mTH) antigens. Vaccination was effective in… Expand
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