DNA Methyltransferase Inhibitors: Development and Applications.

  title={DNA Methyltransferase Inhibitors: Development and Applications.},
  author={Marie Lopez and Ludovic Halby and Paola B. Arimondo},
  journal={Advances in experimental medicine and biology},
As described in previous chapters of this book, DNA methylation is involved in numerous biological processes, and modulation of the activity of DNA methyltransferases (DNMTs) is a powerful strategy to modulate, restore, or reduce DNA methylation. In this chapter, we will present examples of inhibitors of DNMTs (DNMTi) and review the fields of applications of DNMTi mainly as therapeutic molecules, for example, in cancers, cardiovascular or neurological diseases, but also as bioengineering tools… CONTINUE READING