DNA Methylation in the Rectal Mucosa Is Associated with Crypt Proliferation and Fecal Short-Chain Fatty Acids

Abstract

DNA methylation varies throughout the normal colorectal mucosa and DNA methylation in normal appearing mucosa is associated with serrated and adenomatous neoplasia elsewhere within the colorectum. The purpose of this study was to measure luminal chemistry, rectal proliferation and mucosal DNA methylation and thus determine whether regional and pathological… (More)
DOI: 10.1007/s10620-010-1312-4

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@article{Worthley2010DNAMI, title={DNA Methylation in the Rectal Mucosa Is Associated with Crypt Proliferation and Fecal Short-Chain Fatty Acids}, author={Daniel L. Worthley and Vicki L. J. Whitehall and Richard K. Le Leu and Natsumi Irahara and Ronald L. Buttenshaw and Kylie-ann Mallitt and Sonia Greco and Ingunn Ramsnes and Jean Michel Winter and Ying Hu and Shuji Ogino and Graeme P. Young and Barbara A. Leggett}, journal={Digestive Diseases and Sciences}, year={2010}, volume={56}, pages={387-396} }