DNA Methylation in the Malignant Transformation of Meningiomas

  title={DNA Methylation in the Malignant Transformation of Meningiomas},
  author={Fan Gao and Lingling Shi and Jonathan J. Russin and Liyun Zeng and Xiao Chang and Shuhan He and Thomas C. Chen and Steven l. Giannotta and Daniel J Weisenberger and Gabriel Zada and William J. Mack and Kai Wang},
  booktitle={PloS one},
Meningiomas are central nervous system tumors that originate from the meningeal coverings of the brain and spinal cord. Most meningiomas are pathologically benign or atypical, but 3-5% display malignant features. Despite previous studies on benign and atypical meningiomas, the key molecular pathways involved in malignant transformation remain to be determined, as does the extent of epigenetic alteration in malignant meningiomas. In this study, we explored the landscape of DNA methylation in ten… CONTINUE READING
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