DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes

@inproceedings{Gervin2012DNAMA,
  title={DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes},
  author={Kristina Gervin and Magnus D. Vigeland and Morten Mattingsdal and Martin Hammer\o and Heidi Nyg{\aa}rd and Anne Olaug Olsen and Ingunn Brandt and Jennifer Ruth Harris and Dag Erik Undlien and Robert Lyle},
  booktitle={PLoS genetics},
  year={2012}
}
Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for example, discordance rates for autoimmune diseases are 20%-80%. MZ discordance indicates a role for epigenetic or environmental factors in disease. We used MZ twins discordant for psoriasis to search for genome-wide differences in DNA methylation and gene expression in CD4(+) and CD8(+) cells using Illumina's HumanMethylation27 and HT-12 expression assays, respectively. Analysis of these data revealed no… CONTINUE READING
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