DNA Methylation and Demethylation as Targets for Anticancer Therapy

@article{Szyf2005DNAMA,
  title={DNA Methylation and Demethylation as Targets for Anticancer Therapy},
  author={Moshe Szyf},
  journal={Biochemistry (Moscow)},
  year={2005},
  volume={70},
  pages={533-549}
}
Cancer growth and metastasis require the coordinate change in gene expression of different sets of genes. While genetic alterations can account for some of these changes, it is becoming evident that many of the changes in gene expression observed are caused by epigenetic modifications. The epigenome consists of the chromatin and its modifications, the “histone code” as well as the pattern of distribution of covalent modifications of cytosines residing in the dinucleotide sequence CG by… CONTINUE READING