DNA Methylation Profiling Identifies EYA4 Gene as a Prognostic Molecular Marker in Hepatocellular Carcinoma

@article{Hou2013DNAMP,
  title={DNA Methylation Profiling Identifies EYA4 Gene as a Prognostic Molecular Marker in Hepatocellular Carcinoma},
  author={Xun Hou and Jian-xin Peng and Xiao-Yi Hao and J. Cai and L. Liang and Jing-ming Zhai and Kun Zhang and J. Lai and X. Yin},
  journal={Annals of Surgical Oncology},
  year={2013},
  volume={21},
  pages={3891-3899}
}
AbstractBackground DNA hypermethylation plays important roles in carcinogenesis by silencing key genes. This study aims to identify pivotal genes in hepatocellular carcinoma (HCC) by DNA methylation microarray and to assess their prognostic values.Materials and MethodsDNA methylation microarray was performed in 45 pairs of HCC and adjacent nontumorous tissues and six normal liver tissues to identify hypermethylated genes in HCC. Potential prognosis-related genes were selected among… Expand
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EYA4 serves as a prognostic biomarker in hepatocellular carcinoma and suppresses tumour angiogenesis and metastasis
  • F. Gu, S. Yuan, +4 authors W. Zhou
  • Biology, Medicine
  • Journal of cellular and molecular medicine
  • 2019
TLDR
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TLDR
This study suggests that EYA4 can be used as a prognostic marker and provide a potential therapeutic target in LGG patients with IDH1 mutation and 1p19q co-deletion. Expand
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TLDR
The restoration of EYA4 expression in HCC cell lines suppressed cell proliferation, inhibited clonogenic outgrowth, reduced cell invasion and restrained xenograft tumor growth, and Flag-RAP1A reversed the suppressive effects of pEYA4 in vitro. Expand
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