DNA Methylation: Roles in Rheumatoid Arthritis

  title={DNA Methylation: Roles in Rheumatoid Arthritis},
  author={Feng-Lai Yuan and Xia Chong Li and Rui-sheng Xu and Dong-Lin Jiang and Xiao-Gang Zhou},
  journal={Cell Biochemistry and Biophysics},
Rheumatoid arthritis (RA) is an immune-mediated disease of unknown cause that primarily affects the joints and ultimately leads to joint destruction. In recent years, the potential role of DNA methylation in the development of RA is raising great expectations among clinicians and researchers. DNA methylation influences diverse aspects of the disease and regulates epigenetic silencing of genes and behavior of several cell types, especially fibroblast-like synoviocytes (FLS), the most resident… CONTINUE READING

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