DNA Methylation: An Introduction to the Biology and the Disease-Associated Changes of a Promising Biomarker

@article{Tost2010DNAMA,
  title={DNA Methylation: An Introduction to the Biology and the Disease-Associated Changes of a Promising Biomarker},
  author={J. Tost},
  journal={Molecular Biotechnology},
  year={2010},
  volume={44},
  pages={71-81}
}
  • J. Tost
  • Published 2010
  • Biology, Medicine
  • Molecular Biotechnology
DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic mechanisms controlling and modulating gene expression through chromatin structure. It closely interacts with histone modifications and chromatin remodeling complexes to form the genomic chromatin landscape. DNA methylation is essential for proper mammalian development, crucial for imprinting and plays a role in maintaining… Expand
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References

SHOWING 1-10 OF 95 REFERENCES
Regulation of imprinted DNA methylation
  • 59
Cancer epigenetics.
  • P. Laird
  • Medicine
  • Human molecular genetics
  • 2005
  • 651
  • PDF
DNA methylation reprogramming in the germ line
  • 57
Genomic DNA methylation: the mark and its mediators.
  • 2,251
  • PDF
The impact of metabolism on DNA methylation.
  • 269
  • Highly Influential
  • PDF
Dynamic regulation of DNA methylation during mammalian development.
  • 45
DNA methylation in cancer: too much, but also too little
  • 1,341
  • PDF
DNA methylation and human disease
  • 2,191
  • PDF
Chromatin remodeling, histone modifications, and DNA methylation—how does it all fit together?
  • 290
  • PDF
...
1
2
3
4
5
...