DNA-Mediated Cellular Delivery of Functional Enzymes.

  title={DNA-Mediated Cellular Delivery of Functional Enzymes.},
  author={Jeffrey D. Brodin and Anthony J. Sprangers and Janet R McMillan and Chad A. Mirkin},
  journal={Journal of the American Chemical Society},
  volume={137 47},
We report a strategy for creating a new class of protein transfection materials composed of a functional protein core chemically modified with a dense shell of oligonucleotides. These materials retain the native structure and catalytic ability of the hydrolytic enzyme β-galactosidase, which serves as the protein core, despite the functionalization of its surface with ∼25 DNA strands. The covalent attachment of a shell of oligonucleotides to the surface of β-galactosidase enhances its cellular… CONTINUE READING
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