DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

@inproceedings{Simsek2011DNALI,
  title={DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation},
  author={Deniz Simsek and Erika C. Brunet and Sunnie Yan-Wai Wong and Sachin Katyal and Yankun Gao and Peter J Mckinnon and Jacqueline F. Lou and Lei Zhang and James Wq Li and Edward J. Rebar and Philip D. Gregory and Michael C. Holmes and Maria Jasin},
  booktitle={PLoS genetics},
  year={2011}
}
Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells. The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instability and chromosomal translocations, leading to the notion that a poorly defined, alternative NHEJ (alt-NHEJ) pathway generates these rearrangements. Here, we investigate the DNA ligase requirement of chromosomal translocation formation in mouse… CONTINUE READING
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