DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development

  title={DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development},
  author={Yosuke Ichijima and Ken-ichi Yoshioka and Y. Yoshioka and Keitaro Shinohe and H. Fujimori and J. Unno and M. Takagi and H. Goto and M. Inagaki and S. Mizutani and H. Teraoka},
  journal={PLoS ONE},
  • Yosuke Ichijima, Ken-ichi Yoshioka, +8 authors H. Teraoka
  • Published 2010
  • Biology, Medicine
  • PLoS ONE
  • During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during the process of tumorigenesis. Here, we show that precancerous DNA lesions induced by oncogene acceleration, which induce situations identical to the initial stages of cancer development, trigger tetraploidy/aneuploidy generation in association with mitotic aberration. Although oncogene acceleration… CONTINUE READING

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