DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development

@inproceedings{Ichijima2010DNALI,
  title={DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration
                    and Tetraploidy Development},
  author={Yosuke Ichijima and Ken-ichi Yoshioka and Yoshiko Yoshioka and Keitaro Shinohe and Hiroaki Fujimori and Junya Unno and Masatoshi Takagi and Hidemasa Goto and Masaki Inagaki and Shutaro Mizutani and Hirobumi Teraoka},
  booktitle={PloS one},
  year={2010}
}
During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during the process of tumorigenesis. Here, we show that precancerous DNA lesions induced by oncogene acceleration, which induce situations identical to the initial stages of cancer development, trigger tetraploidy/aneuploidy generation in association with mitotic aberration. Although oncogene acceleration… CONTINUE READING

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