DNA Isolation Method Is a Source of Global DNA Methylation Variability Measured with LUMA. Experimental Analysis and a Systematic Review

@inproceedings{SorianoTrraga2013DNAIM,
  title={DNA Isolation Method Is a Source of Global DNA Methylation Variability Measured with LUMA. Experimental Analysis and a Systematic Review},
  author={Carolina Soriano-T{\'a}rraga and Jordi Jim{\'e}nez-Conde and E Giralt-Steinhauer and {\'A}ngel Ois and Ana Rodr{\'i}guez-Campello and Elisa Cuadrado-God{\'i}a and Israel Fern{\'a}ndez-Cadenas and J Montaner and Gavin Lucas and Roberto Elos{\'u}a and J Roquer},
  booktitle={PloS one},
  year={2013}
}
In DNA methylation, methyl groups are covalently bound to CpG dinucleotides. However, the assumption that methyl groups are not lost during routine DNA extraction has not been empirically tested. To avoid nonbiological associations in DNA methylation studies, it is essential to account for potential batch effect bias in the assessment of this epigenetic mechanism. Our purpose was to determine if the DNA isolation method is an independent source of variability in methylation status. We… CONTINUE READING
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