DNA Interstrand Cross-Linking Reactions of Pyrrole-Derived , Bifunctional Electrophiles : Evidence for a Common Target Site in DNA

@inproceedings{Woo2001DNAIC,
  title={DNA Interstrand Cross-Linking Reactions of Pyrrole-Derived , Bifunctional Electrophiles : Evidence for a Common Target Site in DNA},
  author={Jinsuk Woo and Snorri Th. Sigurdsson and Paul B. Hopkins},
  year={2001}
}
The site of DNA interstrand cross-linking identified by a family of pyrrole-derived bifunctional electrophiles was studied in vitro in synthetic DNA duplexes. This family includes reductively activated mitomycin C (l), oxidatively activated pyrrolizidine alkaloids (e.g. 2), the simple pyrroles 2,3and 3,4-bis-(acetoxymethyl)1-methylpyrrole (3 and 4), and the antitumor substance 2,3-dihydro-5-(3’,4’-dichlorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine bis(isopropylcarbamate) (IPP, 5). It is… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-2 of 2 references

Helu

  • M. Viscontini, H. Gillhof-Schaufelberger
  • Chim . Acta
  • 1971

Covalent Crosslinks and Monofunctional Adducts of Mitomycin C in the Minor Groove of DNA : Effects on DNA Conformation and Dynamics

  • R. W. Franck, A. K. Chawla, R. Lipman, M. Tomasz

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