DNA H form requires a homopurine–homopyrimidine mirror repeat

Regular homopurine-homopyrimidine tracts, (dG–dA)n·(dT–dC)n and (dG)R·(dC)n, undergo a superhelix-induced, strongly pH-dependent, structural transition into a novel DNA conformation, the H form1–3. We have suggested that the H form can arise in any homopurine-homopyrimidine mirror repeat (H palindrome)3. We have now tested this prediction using a tailored… CONTINUE READING