DNA-Functionalized Nanotube Membranes with Single-Base Mismatch Selectivity

@article{Kohli2004DNAFunctionalizedNM,
  title={DNA-Functionalized Nanotube Membranes with Single-Base Mismatch Selectivity},
  author={P. Kohli and C. Harrell and Z. Cao and Rahela Ga{\vs}parac and W. Tan and C. Martin},
  journal={Science},
  year={2004},
  volume={305},
  pages={984 - 986}
}
  • P. Kohli, C. Harrell, +3 authors C. Martin
  • Published 2004
  • Chemistry, Medicine
  • Science
  • We describe synthetic membranes in which the molecular recognition chemistry used to accomplish selective permeation is DNA hybridization. These membranes contain template-synthesized gold nanotubes with inside diameters of 12 nanometers, and a “transporter” DNA-hairpin molecule is attached to the inside walls of these nanotubes. These DNA-functionalized nanotube membranes selectively recognize and transport the DNA strand that is complementary to the transporter strand, relative to DNA strands… CONTINUE READING
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