DNA-Functionalized Nanotube Membranes with Single-Base Mismatch Selectivity
@article{Kohli2004DNAFunctionalizedNM, title={DNA-Functionalized Nanotube Membranes with Single-Base Mismatch Selectivity}, author={P. Kohli and C. Harrell and Z. Cao and Rahela Ga{\vs}parac and W. Tan and C. Martin}, journal={Science}, year={2004}, volume={305}, pages={984 - 986} }
We describe synthetic membranes in which the molecular recognition chemistry used to accomplish selective permeation is DNA hybridization. These membranes contain template-synthesized gold nanotubes with inside diameters of 12 nanometers, and a “transporter” DNA-hairpin molecule is attached to the inside walls of these nanotubes. These DNA-functionalized nanotube membranes selectively recognize and transport the DNA strand that is complementary to the transporter strand, relative to DNA strands… CONTINUE READING
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