DNA Double Strand Break Repair and its Association with Inherited Predispositions to Breast Cancer


Mutations in BRCA1 account for the majority of familial aggregations of early onset breast and ovarian cancer (~70%) and about 1/5 of all early onset breast cancer families; in contrast, mutations in BRCA2 account for a smaller proportion of breast/ovarian cancer families and a similar proportion of early onset breast cancer families. BRCA2 has also been… (More)
DOI: 10.1186/1897-4287-2-1-37


3 Figures and Tables