DNA Damage as the Primary Cause of Aging

@article{Gensler1981DNADA,
  title={DNA Damage as the Primary Cause of Aging},
  author={Helen Lynch Gensler and Harris Bernstein},
  journal={The Quarterly Review of Biology},
  year={1981},
  volume={56},
  pages={279 - 303}
}
DNA damage appears to be ubiquitous in the biological world, as judged by the variety of organisms which have evolved DNA-repair systems. Previously, it was proposed that germ-line DNA of multicellular organisms may be protected from damage, and consequently from aging, by efficient recombinational repair during meiosis. The somatic line, however, may be vulnerable to the accumulation of DNA damage, and hence undergo aging, owing to relatively less repair. Although DNA Lesions most important in… Expand
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