DNA Damage as the Primary Cause of Aging

  title={DNA Damage as the Primary Cause of Aging},
  author={Helen Lynch Gensler and Harris Bernstein},
  journal={The Quarterly Review of Biology},
  pages={279 - 303}
DNA damage appears to be ubiquitous in the biological world, as judged by the variety of organisms which have evolved DNA-repair systems. Previously, it was proposed that germ-line DNA of multicellular organisms may be protected from damage, and consequently from aging, by efficient recombinational repair during meiosis. The somatic line, however, may be vulnerable to the accumulation of DNA damage, and hence undergo aging, owing to relatively less repair. Although DNA Lesions most important in… 

DNA damage and repair during cellular aging.

  • S. Rattan
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    International review of cytology
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A review and appraisal of the DNA damage theory of ageing.

Genomic damage and its repair in young and aging brain

It is suggested that assessment of repair potential of neurons with respect to a specific damage in a specific gene might yield more definitive answers about the DNA-repair process and its role in aging.

DNA Polymerase‐β May Be the Main Player for Defective DNA Repair in Aging Rat Neurons

Findings are taken to indicate an age‐dependent decline in the DNA repair capacity of neurons and that DNA polymerase β is a key player in theDNA repair mechanisms of nerve cells.

Recombinational Repair May be an Important Function of Sexual Reproduction

Experimental information on recombinationalrepair in the various organisms that have been studied, on the range of organisms that use recombinational repair, onThe variety of lesions against which it acts, and on its efficiency in overcoming DNA damage are reviewed to support the hypothesis that recombinational Repair is a major function of sexual reproduction.

Fight to the bitter end: DNA repair and aging




DNA repair in bacteria and mammalian cells.

Since bacterial excision repair was last reviewed not only has the understanding of previously recognized mechanisms increased, but new mechanisms have been described which have broadened the concept

On the possibility that DNA repair is related to age in non-dividing cells.

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  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1974
Possible age-related deterioration in the efficacy of DNA repair was investigated in a complement of non-dividing mammalian cells which is not replenished during the lifetime of the animal. Internal

Longevity, stability and DNA repair

Role of DNA Repair in Aging

It is reasonable to assume that if any single molecular target for the aging phenomenon does exist, it must be related not only to age-related diseases, but also play a central role in several cellular processes.

Human Diseases Associated with Defective DNA Repair

Single-stranded regions in DNA of old mice

The physical state of the DNA of senescing mice is studied, and the accumulation of an increasing amount of single-stranded regions in the DNA with age is reported.

Genetic factors in aging.


Evolution of Sexual Reproduction: Importance of DNA Repair, Complementation, and Variation

It is argued that a complete evolutionary explanation for the maintenance of sexual reproduction should also include complementation and DNA repair.

Developmental decline in DNA repair in neural retina cells of chick embryos: persistent deficiency of repair competence in a cell line derived from late

Possible correlations between deficiency in DNA repair mechanisms in replicating cells and carcinogenesis in neural tissues are discussed.