DNA Damage and Cellular Stress Responses Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents


The Fanconi anemia pathway is required for repair of DNA interstrand cross-links (ICL). Fanconi anemia pathway–deficient cells are hypersensitive to DNA ICL–inducing drugs such as cisplatin. Conversely, hyperactivation of the Fanconi anemia pathway is a mechanism that may underlie cellular resistance to DNA ICL agents. Modulating FANCD2 monoubiquitination… (More)


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