DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3

  title={DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3},
  author={Suzette E. Farber-Katz and Holly C. Dippold and Matthew D. Buschman and Marshall C. Peterman and Mengke Xing and Christopher J. Noakes and John Tat and Michelle M. Ng and Juliati Rahajeng and David S M Cowan and Greg J. Fuchs and Huilin Zhou and Seth J. Field},
The response to DNA damage, which regulates nuclear processes such as DNA repair, transcription, and cell cycle, has been studied thoroughly. However, the cytoplasmic response to DNA damage is poorly understood. Here, we demonstrate that DNA damage triggers dramatic reorganization of the Golgi, resulting in its dispersal throughout the cytoplasm. We further show that DNA-damage-induced Golgi dispersal requires GOLPH3/MYO18A/F-actin and the DNA damage protein kinase, DNA-PK. In response to DNA… CONTINUE READING
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