DNA Damage Triggers Genetic Exchange in Helicobacter pylori

  title={DNA Damage Triggers Genetic Exchange in Helicobacter pylori},
  author={Marion S. Dorer and Jutta B Fero and Nina R Salama},
  booktitle={PLoS pathogens},
Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein that promotes DNA donation from intact cells is also induced. Exogenous DNA modulates the DNA damage response, as both recA and the ability to take up DNA are required for full induction of the… CONTINUE READING
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