DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore

@article{Kim2008DNADA,
  title={DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore},
  author={Eun Mi Kim and Daniel J. Burke},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={433 - 439}
}
The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important regulatory mechanisms that respond to different lesions. The DNA damage checkpoint detects DNA damage, initiates protein kinase cascades, and inhibits the cell cycle. The SAC relies on kinetochore-dependent assembly of protein complexes to inhibit mitosis when chromosomes are detached from the spindle. The two checkpoints are thought to function independently. Here we show that yeast cells lacking the DNA… CONTINUE READING

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