DNA Damage: A Main Determinant of Vascular Aging

  title={DNA Damage: A Main Determinant of Vascular Aging},
  author={Paula K. Bautista-Ni{\~n}o and Eliana Portilla-Fernandez and Douglas E. Vaughan and Alexander Hj Danser and Anton J. M. Roks},
  booktitle={International journal of molecular sciences},
Vascular aging plays a central role in health problems and mortality in older people. Apart from the impact of several classical cardiovascular risk factors on the vasculature, chronological aging remains the single most important determinant of cardiovascular problems. The causative mechanisms by which chronological aging mediates its impact, independently from classical risk factors, remain to be elucidated. In recent years evidence has accumulated that unrepaired DNA damage may play an… CONTINUE READING
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