DNA-Binding Specificities of Human Transcription Factors

@article{Jolma2013DNABindingSO,
  title={DNA-Binding Specificities of Human Transcription Factors},
  author={Arttu Jolma and Jian Yan and Thomas Whitington and Jarkko Toivonen and Kazuhiro R. Nitta and Pasi Rastas and Ekaterina Morgunova and Martin Enge and Mikko Taipale and Gonghong Wei and Kimmo Palin and Juan M. Vaquerizas and Renaud Vincentelli and Nicholas M. Luscombe and Timothy R. Hughes and Patrick Lemaire and Esko Ukkonen and Teemu Kivioja and Jussi Taipale},
  journal={Cell},
  year={2013},
  volume={152},
  pages={327-339}
}
Although the proteins that read the gene regulatory code, transcription factors (TFs), have been largely identified, it is not well known which sequences TFs can recognize. We have analyzed the sequence-specific binding of human TFs using high-throughput SELEX and ChIP sequencing. A total of 830 binding profiles were obtained, describing 239 distinctly different binding specificities. The models represent the majority of human TFs, approximately doubling the coverage compared to existing… CONTINUE READING
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