DNA-Based immunization with Trypanosoma cruzi complement regulatory protein elicits complement lytic antibodies and confers protection against Trypanosoma cruzi infection.

@article{Sepulveda2000DNABasedIW,
  title={DNA-Based immunization with Trypanosoma cruzi complement regulatory protein elicits complement lytic antibodies and confers protection against Trypanosoma cruzi infection.},
  author={Pilar Sepulveda and Mireille Hontebeyrie and P Li{\'e}geard and Alexia D Mascilli and Karen Ann Norris},
  journal={Infection and immunity},
  year={2000},
  volume={68 9},
  pages={4986-91}
}
A complement regulatory protein (CRP) of Trypanosoma cruzi was evaluated as a vaccine candidate in a murine model of experimental T. cruzi infection. Recombinant CRP derived from an Escherichia coli expression system and a plasmid encoding the full-length crp structural gene under the control of a eukaryotic promoter were used to immunize BALB/c mice. Immunization with both protein and DNA vaccines resulted in a Th1-type T-cell response, comparable antibody titers, and similar immunoglobulin G… CONTINUE READING
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