DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases.

@article{Chen2013DNA5D,
  title={DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases.},
  author={Chanyu Chen and Keh-Yang Wang and Che-Kun James Shen},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 13},
  pages={
          9084-91
        }
}
Methylation at the 5-position of DNA cytosine on the vertebrate genomes is accomplished by the combined catalytic actions of three DNA methyltransferases (DNMTs), the de novo enzymes DNMT3A and DNMT3B and the maintenance enzyme DNMT1. Although several metabolic routes have been suggested for demethylation of the vertebrate DNA, whether active DNA demethylase(s) exist has remained elusive. Surprisingly, we have found that the mammalian DNMTs, and likely the vertebrates DNMTs in general, can also… CONTINUE READING
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