DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

Abstract

Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and differentiation. Prior work established doublesex- and mab-3-related transcription factor 1 (Dmrt1) as a conserved transcriptional regulator of male sexual differentiation. Here we investigate the… (More)
DOI: 10.1371/journal.pgen.1006293

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@inproceedings{Zhang2016DMRT1IR, title={DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment}, author={Teng Zhang and Jon Oatley and Vivian J. Bardwell and David A. Zarkower}, booktitle={PLoS genetics}, year={2016} }