DMI-1, a new DNA methyltransferase inhibitor produced by Streptomyces sp. strain No. 560.

@article{Suzuki1995DMI1AN,
  title={DMI-1, a new DNA methyltransferase inhibitor produced by Streptomyces sp. strain No. 560.},
  author={K. Suzuki and K. Nagao and J. Tokunaga and M. Hirosawa and H. Tsubone and M. Uyeda},
  journal={Journal of enzyme inhibition},
  year={1995},
  volume={9 4},
  pages={
          243-52
        }
}
A new inhibitor of DNA methyltransferase named DMI-1 has been discovered in the culture filtrate of Streptomyces sp. strain No. 560. DMI-1 was purified by extraction with ethyl acetate followed by Diaion HP-20SS and silica gel column chromatography. The structure of DMI-1 was determined to be 8-methylpentadecanoic acid (C16H32O2). DMI-1 is a novel inhibitor of methyltransferase isolated from microorganisms and is structurally different from sinefungin and A9145C which are structural analogs of… Expand
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