DMDM: domain mapping of disease mutations

@article{Peterson2010DMDMDM,
  title={DMDM: domain mapping of disease mutations},
  author={Thomas A. Peterson and Asa Adadey and Ivette Santana-Cruz and Yanan Sun and Andrew Winder and Maricel G. Kann},
  journal={Bioinformatics},
  year={2010},
  volume={26 19},
  pages={2458-9}
}
UNLABELLED Domain mapping of disease mutations (DMDM) is a database in which each disease mutation can be displayed by its gene, protein or domain location. DMDM provides a unique domain-level view where all human coding mutations are mapped on the protein domain. To build DMDM, all human proteins were aligned to a database of conserved protein domains using a Hidden Markov Model-based sequence alignment tool (HMMer). The resulting protein-domain alignments were used to provide a domain… CONTINUE READING
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