DMD # 8292 CYP 2 D 6 * 36 gene arrangements within the CYP 2 D 6 locus : Association of CYP 2 D 6 * 36 with poor metabolizer status

@inproceedings{Gaedigk2006DMD8,
  title={DMD # 8292 CYP 2 D 6 * 36 gene arrangements within the CYP 2 D 6 locus : Association of CYP 2 D 6 * 36 with poor metabolizer status},
  author={Andrea Gaedigk and L. DiAnne Bradford and Sarah W. Alander and J Steven Leeder},
  year={2006}
}
Unexplained cases of CYP2D6 genotype/phenotype discordance continue to be discovered. In previous studies several African Americans with a poor metabolizer phenotype carried the reduced function CYP2D6*10 allele in combination with a nonfunctional allele. We pursued the possibility that these alleles harbor either a known sequence variation (i.e. CYP2D6*36… CONTINUE READING