DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours.

@article{Mollenhauer1997DMBT1AN,
  title={DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours.},
  author={Jan Mollenhauer and Stefan Wiemann and Wolfram G. Scheurlen and Bernhard Korn and Yuzo Hayashi and Klaus Kasimir Wilgenbus and Andreas von Deimling and Annemarie Poustka},
  journal={Nature genetics},
  year={1997},
  volume={17 1},
  pages={32-9}
}
Loss of sequences from human chromosome 10q has been associated with the progression of human cancer. Medulloblastoma and glioblastoma multiforme are the most common malignant brain tumours in children and adults, respectively. In glioblastoma multiforme, the most aggressive form, 80% of the tumours show loss of 10q. We have used representational difference analysis to identify a homozygous deletion at 10q25.3-26.1 in a medulloblastoma cell line and have cloned a novel gene, DMBT1, spanning… CONTINUE READING

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