DMB (DNMT-magnetic beads) assay: measuring DNA methyltransferase activity in vitro.

@article{Yokochi2004DMBB,
  title={DMB (DNMT-magnetic beads) assay: measuring DNA methyltransferase activity in vitro.},
  author={Tomoki Yokochi and Keith D. Robertson},
  journal={Methods in molecular biology},
  year={2004},
  volume={287},
  pages={285-96}
}
DNA methylation is an epigenetic modification of DNA that leads to heritable alterations in transcriptional regulation and conformational changes in chromatin structure of higher eukaryotes. Mammalian DNA methyltransferases, which are the enzymes responsible for DNA methylation, have attracted the attention of both basic and clinical researchers because they appear to participate in embryogenesis and carcinogenesis via chromatin modification. DNA methyltransferase catalyzes the transfer of a… CONTINUE READING

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