DLPC decreases TGF-beta1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells.

@article{Cao2002DLPCDT,
  title={DLPC decreases TGF-beta1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells.},
  author={Q Jackie Cao and Ki M. Mak and Charles S. Lieber},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={283 5},
  pages={G1051-61}
}
Dilinoleoylphosphatidylcholine (DLPC), the active component of polyenylphosphatidylcholine extracted from soybeans, decreases collagen accumulation induced by TGF-beta1 in cultured hepatic stellate cells (HSCs). Because DLPC exerts antioxidant effects and TGF-beta1 generates oxidative stress, we evaluated whether the antifibrogenic effect of DLPC is linked to its antioxidant action. In passage 1 culture of rat HSCs, TGF-beta1 induced a concentration-dependent increase in procollagen-alpha(1)(I… CONTINUE READING

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Dilinoleoylphosphatidylcholine (DLPC) decreases transforming growth factor- 1-mediated collagen production by rat hepatic stellate cells

  • Q Cao, K Mak, CS. Lieber
  • J Lab Clin Med
  • 2002
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