DLL4 as a predictor of pelvic lymph node metastasis and a novel prognostic biomarker in patients with early-stage cervical cancer

@article{Yang2015DLL4AA,
  title={DLL4 as a predictor of pelvic lymph node metastasis and a novel prognostic biomarker in patients with early-stage cervical cancer},
  author={Shanshan Yang and Yunduo Liu and Bairong Xia and Jian-Nan Deng and Tianbo Liu and Qi Li and Yanping Yang and Yaoxian Wang and Xiaoming Ning and Yunyan Zhang and Min Xiao},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={5063-5074}
}
Delta-like ligand 4 (DLL4), one of the five Notch signaling ligands in mammals, has an important function in proliferation, invasion, metastasis, progression, and angiogenesis of malignancies. This study aimed to investigate DLL4 expression level in early-stage cervical carcinoma and to evaluate its clinical significance. We used fresh frozen and paraffin-embedded cervical cancer tissues to analyze DLL4 expression and its clinical significance. DLL4 expression at both mRNA and protein levels in… 
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By studying the mechanisms of oncogenes at the molecular level, the functions of their products, and their influence on the vital processes of cells and the whole organism, it is possible to develop ways to treat cancer by inhibition or correcting the work of a particular oncogene or its product.
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Pathway analysis of the microarray expression profile suggested that the TGF-β and p120-associated noncanonical β-catenin pathways are important in pelvic lymph node metastasis in early-stage cervical cancer.
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