DLG5 Variants in Inflammatory Bowel Disease

  title={DLG5 Variants in Inflammatory Bowel Disease},
  author={Carsten Buening and Lars Geerdts and Thomas Fiedler and Enno Gentz and Ghyslaine Pitre and Wolf D. Reuter and Werner Luck and Sabine Buhner and Tomas Molnar and Ferenc Nagy and J{\'a}nos Lonovics and Axel Dignass and Olfert Landt and Renate G. Nickel and Janine Genschel and Herbert Lochs and Hartmut H-J Schmidt and Heiko Witt},
  journal={The American Journal of Gastroenterology},
OBJECTIVES:Genetic variants within DLG5 were recently reported to be associated with inflammatory bowel disease (IBD). The aim of our study was to test for allelic and haplotype associations of six DLG5 variants in 668 IBD patients from two European populations. Furthermore, we evaluated whether DLG5 variants alter gastrointestinal permeability in Crohn's disease (CD).METHODS:Six DLG5 variants (p.R30Q, p.P1371Q, p.G1066G, rs2289308, DLG_e26, p.D1507D) were genotyped in two study populations: (1… CONTINUE READING


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Mutations in the NOD2/CARD15 gene in Crohn’s disease are associated with ileocecal resection and are a risk factor for reoperation

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  • Aliment Pharmacol Ther 2004;19:1073–9
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