DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.

@article{Xue2008DLC1IA,
  title={DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.},
  author={Wen Xue and Alexander Krasnitz and Robert Lucito and Raffaella Sordella and Linda Vanaelst and Carlos Cordon-Cardo and Stephan Singer and Florian K{\"u}hnel and Michael Wigler and Scott Powers and Lars Zender and Scott W Lowe},
  journal={Genes & development},
  year={2008},
  volume={22 11},
  pages={1439-44}
}
Deletions on chromosome 8p are common in human tumors, suggesting that one or more tumor suppressor genes reside in this region. Deleted in Liver Cancer 1 (DLC1) encodes a Rho-GTPase activating protein and is a candidate 8p tumor suppressor. We show that DLC1 knockdown cooperates with Myc to promote hepatocellular carcinoma in mice, and that reintroduction of wild-type DLC1 into hepatoma cells with low DLC1 levels suppresses tumor growth in situ. Cells with reduced DLC1 protein contain… CONTINUE READING
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