DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma.

@article{Kim2007DLC1AG,
  title={DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma.},
  author={Tai Young Kim and Jung Weon Lee and Hwang-phill Kim and Hyun-Soon Jong and T. -Y. Kim and Mira Jung and Yung-jue Bang},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={355 1},
  pages={72-7}
}
DLC-1 (deleted in liver cancer-1) is a tumor suppressor gene for hepatocellular carcinoma and other cancers. To characterize its functions, we constructed recombinant adenovirus encoding the wild-type DLC-1 and examined its effects on behaviors of a hepatocellular carcinoma cell line (SNU-368), which does not express DLC-1. Here, we found that restoration of DLC-1 expression in the SNU-368 cells caused an inhibition of cell proliferation with an increase of a subG1 population. Furthermore, DLC… CONTINUE READING