DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.

@article{Shimamoto1998DLthreobetabenzyloxyaspartateAP,
  title={DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.},
  author={Keiko Shimamoto and B Lebrun and Yoshimi Yasuda-Kamatani and Masahiro Sakaitani and Yasushi Shigeri and Noboru Yumoto and Terumi Nakajima},
  journal={Molecular pharmacology},
  year={1998},
  volume={53 2},
  pages={195-201}
}
DL-threo-beta-Benzyloxyaspartate (DL-TBOA), a novel derivative of DL-threo-beta-hydroxyaspartate, was synthesized and examined as an inhibitor of sodium-dependent glutamate/aspartate (excitatory amino acid) transporters. DL-TBOA inhibited the uptake of [14C]glutamate in COS-1 cells expressing the human excitatory amino acid transporter-1 (EAAT1) (Ki = 42 microM) with almost the same potency as DL-threo-beta-hydroxyaspartate (Ki = 58 microM). With regard to the human excitatory amino acid… CONTINUE READING
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