DL-aminocarnitine and acetyl-DL-aminocarnitine. Potent inhibitors of carnitine acyltransferases and hepatic triglyceride catabolism.

@article{Jenkins1985DLaminocarnitineAA,
  title={DL-aminocarnitine and acetyl-DL-aminocarnitine. Potent inhibitors of carnitine acyltransferases and hepatic triglyceride catabolism.},
  author={D L Jenkins and Owen W. Griffith},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 27},
  pages={
          14748-55
        }
}
  • D. Jenkins, O. Griffith
  • Published 25 November 1985
  • Biology, Computer Science
  • The Journal of biological chemistry
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43 Citations
Methods Citations
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43 Citations

Citation Type

Citation Type

Effect of carnitine acetyltransferase inhibition on rat hepatocyte metabolism.
Active-site probes of carnitine acyltransferases. Inhibition of carnitine acetyltransferase by hemiacetylcarnitinium, a reaction intermediate analogue.
Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines
  • S. Violante, L. Ijlst, S. Houten
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2013
TLDR
CPT2 and CACT are crucial for mitochondrial acylcarnitine formation and export to the extracellular fluids in mFAOD, and results obtained using pharmacological inhibition of CPT2 in fibroblasts from MCAD‐deficient individuals show this.
Inhibition of carnitine acetyltransferase by bile acids: implications for carnitine analysis.
Accumulation and excretion of long-chain acylcarnitine by rat hearts; studies with aminocarnitine.
Characterization of L-aminocarnitine, an inhibitor of fatty acid oxidation.
Kinetic investigation of carnitine palmitoyltransferases in homogenates of human skeletal muscle using L-amino-carnitine and malonyl-CoA.
TLDR
It has been shown that CPT I has a higher molecular size than CPT II due to an additional N-terminal domain consisting of 150 aminoacids and that the different sensitivities of both CPTs to the two inhibitors should allow an experimental approach for the kinetic investigation of both enzymes in homogenates of human skeletal muscle.
Effect of L-carnitine and L-aminocarnitine on calcium transport, motility, and enzyme release from ejaculated bovine spermatozoa.
TLDR
It is concluded that the effects produced by high concentrations of carnitine or aminocarnitine are mainly due to interactions of these compounds with the cellular membranes of spermatozoa.
Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient.
L-carnitine protection in ammonia intoxication. Effect of aminocarnitine on carnitine-dependent metabolism and acute ammonia toxicity.
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