DJ-1 regulation of mitochondrial function and autophagy through oxidative stress.

@article{McCoy2011DJ1RO,
  title={DJ-1 regulation of mitochondrial function and autophagy through oxidative stress.},
  author={Melissa K. McCoy and Mark R Cookson},
  journal={Autophagy},
  year={2011},
  volume={7 5},
  pages={531-2}
}
The dysregulation of mitochondrial function has been implicated in the pathogenesis of Parkinson disease. Mutations in the parkin, PINK1 and DJ-1 genes all result in recessive parkinsonism. Although the protein products of these genes have not been fully characterized, it has been established that all three contribute to the maintenance of mitochondrial function. PINK1 and parkin act in a common pathway to regulate the selective autophagic removal of depolarized mitochondria, but the… CONTINUE READING