DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.

Abstract

Parkinson's disease (PD) is a common neurodegenerative movement disorder. Whereas the majority of PD cases are sporadic, rare genetic defects have been linked to this prevalent movement disorder. Mutations in DJ-1 are associated with autosomal recessive early-onset PD. The exact biochemical function of DJ-1 has remained elusive. Here we report the… (More)

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