DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.

@article{Kishida1999DIXDO,
  title={DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.},
  author={Satoshi Kishida and Hideki Yamamoto and Shin-ichiro Hino and Satoshi Ikeda and Michiko Kishida and Akira Kikuchi},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 6},
  pages={4414-22}
}
The N-terminal region of Dvl-1 (a mammalian Dishevelled homolog) shares 37% identity with the C-terminal region of Axin, and this related region is named the DIX domain. The functions of the DIX domains of Dvl-1 and Axin were investigated. By yeast two-hybrid screening, the DIX domain of Dvl-1 was found to interact with Dvl-3, a second mammalian Dishevelled relative. The DIX domains of Dvl-1 and Dvl-3 directly bound one another. Furthermore, Dvl-1 formed a homo-oligomer. Axin also formed a homo… CONTINUE READING
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