DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts

@inproceedings{Lee2015DISTMIXDI,
  title={DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts},
  author={Donghyung Lee and T. Bernard Bigdeli and Vernell S. Williamson and Vladimir I. Vladimirov and Brien P. Riley and Ayman H. Fanous and Silviu Bacanu},
  booktitle={Bioinformatics},
  year={2015}
}
MOTIVATION To increase the signal resolution for large-scale meta-analyses of genome-wide association studies, genotypes at unmeasured single nucleotide polymorphisms (SNPs) are commonly imputed using large multi-ethnic reference panels. However, the ever increasing size and ethnic diversity of both reference panels and cohorts makes genotype imputation computationally challenging for moderately sized computer clusters. Moreover, genotype imputation requires subject-level genetic data, which… CONTINUE READING
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