DISCUSSION PAPER: SOME BIOCHEMICAL AND PHARMACOLOGIC PROPERTIES OF AMETHOPTERIN‐ALBUMIN *

@article{Jacobs1971DISCUSSIONPS,
  title={DISCUSSION PAPER: SOME BIOCHEMICAL AND PHARMACOLOGIC PROPERTIES OF AMETHOPTERIN‐ALBUMIN *},
  author={Samuel A. Jacobs and M D'Urso-Scott and Joseph R. Bertino},
  journal={Annals of the New York Academy of Sciences},
  year={1971},
  volume={186}
}
The attachment of small molecular weight compounds with biological activity to carrier macromolecules may result in altering the biochemical, pharmacologic and immunologic properties of the small molecular weight substance.', This report is concerned with the alteration in biochemical and pharmacologic properties of amethopterin (Methotrexate) (MTX) when it is covalently attached to albumin. MTX was conjugated to albumin by the carbodiimide reaction which results in amide linkages between one… Expand

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