DISC1 localizes to the centrosome by binding to kendrin.

  title={DISC1 localizes to the centrosome by binding to kendrin.},
  author={Ko Miyoshi and Masato Asanuma and Ikuko Miyazaki and Francisco J. Diaz-Corrales and Taiichi Katayama and Masaya Tohyama and Norio Ogawa},
  journal={Biochemical and biophysical research communications},
  volume={317 4},
Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation that segregated with major mental disorders in a Scottish family. Using the yeast two-hybrid system, we screened a human brain cDNA library for interactors of the DISC1 protein. One of the positive clones encoded kendrin/pericentrin-B, a giant protein known to localize specifically to the centrosome. The interaction between DISC1 and kendrin in mammalian cells was demonstrated by… CONTINUE READING

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