DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development.

@article{GarcaDomingo1999DIO1IA,
  title={DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development.},
  author={David Garc{\'i}a-Domingo and Esther Leonardo and Alf Grandien and Pedro Mart{\'i}nez and Juan P. Albar and Juan Carlos Izpis{\'u}a-Belmonte and Carlos Mart{\'i}nez-A},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 14},
  pages={7992-7}
}
The DIO-1 (death inducer-obliterator-1) gene, identified by differential display PCR in pre-B WOL-1 cells undergoing apoptosis, encodes a putative transcription factor whose protein has two Zn finger motifs, nuclear localization signals, and transcriptional activation domains, expressed in the limb interdigitating webs during development. When overexpressed, DIO-1 translocates to the nucleus and activates apoptosis in vitro. Nuclear translocation as well as induction of apoptosis are lost after… CONTINUE READING
25 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…