DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architecture.

@article{Bnard2006DIG1AN,
  title={DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architecture.},
  author={Claire Y. B{\'e}nard and Alexander Boyanov and David H. Hall and Oliver Hobert},
  journal={Development},
  year={2006},
  volume={133 17},
  pages={3329-40}
}
Dedicated mechanisms exist to maintain the architecture of an animal's nervous system after development is completed. To date, three immunoglobulin superfamily members have been implicated in this process in the nematode Caenorhabditis elegans: the secreted two-Ig domain protein ZIG-4, the FGF receptor EGL-15 and the L1-like SAX-7 protein. These proteins provide crucial information for neuronal structures, such as axons, that allows them to maintain the precise position they acquired during… CONTINUE READING

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