DIF-1, morphogen of Dictyostelium discoideum, induces the erythroid differentiation in murine and human leukemia cells.

@article{Asahi1995DIF1MO,
  title={DIF-1, morphogen of Dictyostelium discoideum, induces the erythroid differentiation in murine and human leukemia cells.},
  author={Ken-ichi Asahi and Atsuko Sakurai and Naoyuki Takahashi and Yuzuru Kubohara and Kuniaki Okamoto and Yasuharu Tanaka},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={208 3},
  pages={
          1036-9
        }
}
The structure of morphogen of Dictyostelium discoideum, DIF-1, which was elucidated by Morris et al. proved to be closely similar to that of differanisole A which had been isolated by us from the metabolites of a simple eucaryote, Chaetomium, as the differentiation-inducer of murine and human undifferentiated tumor cells. This fact seemed to suggest the molecular structure playing an important part in differentiation and development beyond species. We have already examined whether differanisole… CONTINUE READING
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