DIESEL EXHAUST (DE) AFFECTS THE REGULATION OF TESTICULAR FUNCTION IN MALE FISCHER 344 RATS

@article{Tsukue2001DIESELE,
  title={DIESEL EXHAUST (DE) AFFECTS THE REGULATION OF TESTICULAR FUNCTION IN MALE FISCHER 344 RATS},
  author={N. Tsukue and N. Toda and H. Tsubone and M. Sagai and W. Jin and G. Watanabe and K. Taya and J. Birumachi and A. Suzuki},
  journal={Journal of Toxicology and Environmental Health, Part A},
  year={2001},
  volume={63},
  pages={115 - 126}
}
  • N. Tsukue, N. Toda, +6 authors A. Suzuki
  • Published 2001
  • Biology, Medicine
  • Journal of Toxicology and Environmental Health, Part A
To investigate the effects of diesel exhaust (DE) particles on the reproductive system, male Fischer 344 rats at 13 mo of age were exposed to clean air or DE at particle concentrations of 0.3, 1, or 3 mg/m3 for 8 mo. DE did not markedly affect testicular and body weights. However, DE at 0.3 mg/m3 significantly decreased prostate and coagulating gland weights, accompanied by a reduction in thymus and adrenal gland weight. In contrast, there was a significant rise in the weights of prostate… Expand
Effects of inhaled nanoparticle-rich diesel exhaust on regulation of testicular function in adult male rats
TLDR
It is suggested that NR-DE inhalation disrupts the endocrine activity of the male reproductive system and increases testicular ir-inhibin concentrations, but only at 4 weeks. Expand
Effects of 3-methyl-4-nitrophenol in diesel exhaust particles on the regulation of testicular function in immature male rats.
TLDR
It is suggested that PNMC has a direct effect on the testes of immature male rats, causing a reduction in testosterone secretion. Expand
Effect of Diesel Exhaust on Development of Fetal Reproductive Function in ICR Female Mice
TLDR
Female fetuses of pregnant mice exposed to DE in utero are less sensitive to the expression levels of mRNAs for Ad4BP/SF-1 and MIS compared with males and that DE may affect development of the oocyte in the female fetus. Expand
4-Nitrophenol isolated from diesel exhaust particles disrupts regulation of reproductive hormones in immature male rats
TLDR
Findings clearly show that PNP influences the hypothalamic–pituitary–gonadal axis in immature male rats, with decreased secretion of LH and FSH and increased secretion of testosterone and inhibin. Expand
Effect of nanoparticle-rich diesel exhaust on testosterone biosynthesis in adult male mice
The effect of nanoparticle-rich diesel exhaust (NR-DE) on the testicular function and factors related with the biosynthesis of testosterone gene expression were investigated in mice. Male C57BL/JclExpand
Effects of exposure to nanoparticle-rich diesel exhaust on adrenocortical function in adult male mice.
TLDR
Exposure to NR-DE or F-DE may disrupt adrenocortical function in adult male mice and administration of ACTH resulted in a dose-dependent increase in corticosterone and progesterone release in mice-exposed to low-concentrationNR-DE and clean air. Expand
DIESEL EXHAUST AFFECTS THE ABNORMAL DELIVERY IN PREGNANT MICE AND THE GROWTH OF THEIR YOUNG
TLDR
The results show that toxic substances in DE might cause abnormal delivery in mice, and that exposed females affected the growth and sexual maturation of their young. Expand
Exposure to 3-methyl-4-nitrophenol affects testicular morphology and induces spermatogenic cell apoptosis in immature male rats.
TLDR
Results suggest that PNMC exerts its gonadotoxicity in the rat mainly via apoptosis, with a significant decrease in the plasma testosterone levels and in the absolute and relative weights of the testes. Expand
Impairment of testicular function in adult male Japanese quail (Coturnix japonica) after a single administration of 3-methyl-4-nitrophenol in diesel exhaust particles.
TLDR
It is suggested that PNMC acts on the hypothalamus-pituitary axis, by reducing circulating LH within a few hours of administration and subsequently reducing testosterone secretion, and disrupts testicular function in adult male quail. Expand
Diesel exhaust particle toxicity on spermatogenesis in the mouse is aryl hydrocarbon receptor dependent.
TLDR
It is clearly demonstrated that DEPs suppress testicular function, especially spermatogenesis and sperm motility, which may be AhR dependent. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Exposure to diesel exhaust affects the male reproductive system of mice.
TLDR
It is proposed here that diesel exhaust is an environmental pollutant with the potential to influence male reproductive function and a no-observed-adverse-effect level (NOAEL) was observed with approximately 30 micrograms DEP/m3, which is lower than the WHO-recommended limit. Expand
Inhalation of diesel engine exhaust affects spermatogenesis in growing male rats.
TLDR
It is suggested that diesel exhaust stimulates hormonal secretion of the adrenal cortex, depresses gonadotropin-releasing-hormone, and inhibits spermatogenesis in rats, and the gaseous phase of the exhaust appears to be more responsible than particulate matter for disrupting the endocrine system. Expand
Long-term exposure to diesel exhaust enhances antigen-induced eosinophilic inflammation and epithelial damage in the murine airway.
TLDR
It is concluded that the combination of antigen and chronic exposure to DE produces increased eosinophilic inflammation, and cell damage to the epithelium may depend on the degree of eosInPhilic inflammation in the airway. Expand
Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse.
TLDR
It was suggested that most parts of DEP toxicity in lungs are due to active oxygen radicals such as O2.- and .OH, and that the cause of death is due to pulmonary edema mediated by endothelial cell damage. Expand
Biological effects of diesel exhaust particles (DEP). II. Acute toxicity of DEP introduced into lung by intratracheal instillation.
TLDR
Results may suggest that damage of capillary endothelial cells and type I pneumocytes are the earliest changes of lung toxicities by DEP and these cell injuries lead to alveolar oedema and the subsequent inflammatory response. Expand
8-Hydroxyguanosine formed in human lung tissues and the association with diesel exhaust particles.
TLDR
Results suggest that carboneceous particles, but not mutagens and carcinogens, promote the formation of 8-OHdG, and that as a mechanism, alveolar macrophages may be involved in oxidative damage. Expand
Mutagenicity of scooter exhaust particulate matter.
  • W. Zhou, S. Ye
  • Chemistry, Medicine
  • Journal of toxicology and environmental health
  • 1997
By using the in vitro Ames Salmonella/microsomal assay and the in vivo mouse micronucleus assay, studies were performed to evaluate the genotoxicity of gasoline exhaust particulate matter generatedExpand
Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues.
TLDR
It is shown that ME and MEP extract contain substances that can induce multiple forms of P-450 and glutathione S-transferase activity in the rat. Expand
Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice.
TLDR
It is suggested that diesel exhaust particles instilled intratracheally and repeatedly to mice (once/week for 16 weeks) caused marked infiltration of inflammatory cells, proliferation of goblet cells, increased mucus secretion, respiratory resistance, and airway constriction, and bronchial asthma in mice. Expand
Review Article: Strain as a Determinant Factor in the Differential Responsiveness of Rats to Chemicals
TLDR
There are differences in the responsiveness of rat strains to chemicals and that the susceptibility observed is dependent on the tissue examined, which indicates that the genotype differs among strains, and this may be responsible for differences in sensitivities to chemicals. Expand
...
1
2
3
4
...