DICER1 mutations in familial pleuropulmonary blastoma.

@article{Hill2009DICER1MI,
  title={DICER1 mutations in familial pleuropulmonary blastoma.},
  author={Dana Ashley Hill and Jennifer L. Ivanovich and John R. Priest and Christina A. Gurnett and Louis P. Dehner and David Michael Desruisseau and Jason A. Jarzembowski and Kathryn Wikenheiser-brokamp and Brian K. Suarez and Alison J. Whelan and Gretchen Williams and Dawn Bracamontes and Yoav H Messinger and Paul J Goodfellow},
  journal={Science},
  year={2009},
  volume={325 5943},
  pages={965}
}
Pleuropulmonary blastoma (PPB) is a rare pediatric lung tumor that is often part of an inherited cancer syndrome. PPBs consist of mesenchymal cells that are susceptible to malignant transformation and cysts lined by epithelial cells. In a subset of patients, overgrowth of the cysts by mesenchymal cells leads to sarcoma formation. Here, we show that 11 multiplex PPB families harbor heterozygous germline mutations in DICER1, a gene encoding an endoribonuclease critical to the generation of small… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 197 extracted citations

RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment

Journal of cancer prevention • 2017
View 8 Excerpts
Highly Influenced

Dysregulation of microRNA biogenesis machinery in cancer.

Critical reviews in biochemistry and molecular biology • 2016
View 14 Excerpts
Highly Influenced

Gynecologic Manifestations of the DICER1 Syndrome.

Surgical pathology clinics • 2016
View 4 Excerpts
Highly Influenced

Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome

European Journal of Pediatrics • 2015
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…